Structure of PDB 4ysj Chain A

Receptor sequence

>4ysjA (length=459) Species: 5802 (Eimeria tenella) [Search protein sequence]

KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVK
VISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEI
ISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDAN
IRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLA
YVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALL
YMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDV
SALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLER
AFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFE
EFRQMLLKL

3D structure

PDB

4ysj Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

Chain

Resolution

2.7 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D151 K153 E155 N156 D172 T191
Catalytic site (residue number reindexed from 1)	D134 K136 E138 N139 D155 T174
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	D345 N347 D349 Q351 E356	D323 N325 D327 Q329 E334
BS02	CA	A	D392 D394 N396 F398 E400 E403	D370 D372 N374 F376 E378 E381
BS03	CA	A	D428 D430 S432 K434 E439	D406 D408 S410 K412 E417
BS04	CA	A	D462 N464 D466 E468 E473	D440 N442 D444 E446 E451
BS05	MG	A	N156 D172	N139 D155
BS06	ADP	A	G37 V42 A55 K57 Y108 E112 L158 I171 D172	G30 V35 A48 K50 Y91 E95 L141 I154 D155

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calcium/calmodulin-dependent protein kinase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0009931	calcium-dependent protein serine/threonine kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4ysj, PDBe:4ysj, PDBj:4ysj
PDBsum	4ysj
PubMed
UniProt	Q3HNM4

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