Structure of PDB 4ys0 Chain A

Receptor sequence

>4ys0A (length=814) Species: 243274 (Thermotoga maritima MSB8)

ILFDKNKRILKKYAKMVSKINQIESDLRSKKNSELIRLSMVLKEKVNSFE
DADEHLFEAFALVREAARRTLGMRPFDVQVMGGIALHEGKVAEMKTGEGK
TLAATMPIYLNALIGKGVHLVTVNDYLARRDALWMGPVYLFLGLRVGVIN
SLGKSYEVVWKNPDLARKAIEENWSVWPDGFNGEVLKEESMNKEAVEAFQ
VELKEITRKEAYLCDVTYGTNNEFGFDYLRDNLVLDYNDKVQRGHFYAIV
DEADSVLIDEARTPLIISGPSKESPSVYRRFAQIAKKFVKDKDFTVDEKA
RTIILTEEGVAKAEKIIGVENLYDPGNVSLLYHLINALKALHLFKKDVDY
VVMNGEVIIVDEFTGRLLPGRRYSGGLHQAIEAKEGVPIKEESITYATIT
FQNYFRMYEKLAGMTGTAKTEESEFVQVYGMEVVVIPTHKPMIRKDHDDL
VFRTQKEKYEKIVEEIEKRYKKGQPVLVGTTSIEKSELLSSMLKKKGIPH
QVLNAKYHEKEAEIVAKAGQKGMVTIATNMAGRGTDIKLGPGVAELGGLC
IIGTERHESRRIDNQLRGRAGRQGDPGESIFFLSLEDDLLRIFGSEQIGK
VMNILKIEEGQPIQHPMLSKLIENIQKKVEGINFSIRKTLMEMDDVLDKQ
RRAVYSLRDQILLEKDYDEYLKDIFEDVVSTRVEEFCSGKNWDIESLKNS
LSFFPAGLFDLDEKQFSSSEELHDYLFNRLWEEYQRKKQEIGEDYRKVIR
FLMLRIIDDHWRRYLEEVEHVKEAVQLRSDPIVEFKKETYYMFDEMMRRI
NDTIANYVLRVLEH

3D structure

• PDB: 4ys0 Conformational Changes of the Clamp of the Protein Translocation ATPase SecA.
• Chain: A
• Resolution: 1.897 Å

Enzymatic activity

• Enzyme Commision number: 7.4.2.8: protein-secreting ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	R75 F77 Q80 G98 G100 K101 T102 W135 D537	R74 F76 Q79 G97 G99 K100 T101 W134 D536

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008564 protein-exporting ATPase activity

Biological Process

• GO:0006605 protein targeting
• GO:0006886 intracellular protein transport
• GO:0015031 protein transport
• GO:0017038 protein import
• GO:0043952 protein transport by the Sec complex
• GO:0065002 intracellular protein transmembrane transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0031522 cell envelope Sec protein transport complex

External links

• PDB: RCSB:4ys0, PDBe:4ys0, PDBj:4ys0
• PDBsum: 4ys0
• PubMed: 25982945
• UniProt: Q9X1R4|SECA_THEMA Protein translocase subunit SecA (Gene Name=secA)