Structure of PDB 4yru Chain A

Receptor sequence
>4yruA (length=151) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFA
TFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGY
ITRNEMLDIVDAIYQMVGNTTPEKRVDRIFAMMDKNADGKLTLQEFQEGS
K
3D structure
PDB4yru Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D73 N75 D77 R79 E81 E84 D58 N60 D62 R64 E66 E69
BS02 CA A D109 D111 D113 Y115 E120 D94 D96 D98 Y100 E105
BS03 CA A D157 N159 D161 K163 E168 D134 N136 D138 K140 E145
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0008427 calcium-dependent protein kinase inhibitor activity
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0010975 regulation of neuron projection development
GO:0045921 positive regulation of exocytosis
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070588 calcium ion transmembrane transport
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
GO:2000300 regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0044305 calyx of Held
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yru, PDBe:4yru, PDBj:4yru
PDBsum4yru
PubMed25979333
UniProtP62168|NCS1_RAT Neuronal calcium sensor 1 (Gene Name=Ncs1)

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