Structure of PDB 4yrq Chain A

Receptor sequence
>4yrqA (length=412) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
MVETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLESEEL
YIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAK
WYSIPQCWRYERRREHYQWNMDIVGVKSVSAEVELVCAACWAMRSLGLSS
KDVGIKVNSRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVEAQLA
VLGPTVVDAITTTLSLKSIDEIAQRVGEEHEAVKELRQFFEQVEAYGYGD
WVLFDASVVRGLAYYTGIVFEGFDREGKFRALCGGGRYDNLLTTYGSPTP
IPCAGFGFGDCVIVELLQEKRLLPDIPHVVDDVVIPFDESMRPHALAVLR
RLRDAGRSADIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERGEVQVKM
LRGFAVPLDRLV
3D structure
PDB4yrq A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS A T128 Q170 D174 L316 Y318 Y319 G359 F360 T81 Q118 D122 L262 Y264 Y265 G305 F306
BS02 4JQ A P125 R156 R165 R166 E167 H168 P78 R109 R113 R114 E115 H116
Gene Ontology
Molecular Function
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yrq, PDBe:4yrq, PDBj:4yrq
PDBsum4yrq
PubMed26249349
UniProtQ4DA54

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