Structure of PDB 4yrk Chain A

Receptor sequence
>4yrkA (length=411) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
MVETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLESEEL
YIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAK
WYSIPQCWRYERRREHYQWNMDIVGVKSVSAEVELVCAACWAMRSLGLSS
KDVGIKVNSRKVLQTVVEQAGVTSDKFAPVCVIVDKMREEVEAQLAVLGL
EPTVVDAITTTLSLKSIDEIAQRVGEEHEAVKELRQFFEQVEAYGYGDWV
LFDASVVRGLAYYTGIVFEGFDREGKFRALCGGGRYDNLLTTYGSPTPIP
CAGFGFGDCVIVELLQEKRLLPDIPHVVDDVVIPFDESMRPHALAVLRRL
RDAGRSADIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERGEVQVKMLR
RGFAVPLDRLV
3D structure
PDB4yrk A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS A T128 D174 L316 Y318 Y319 G359 F360 G361 T81 D122 L260 Y262 Y263 G303 F304 G305
BS02 4JL A I106 W155 R156 R165 E167 H168 I59 W108 R109 R113 E115 H116
Gene Ontology
Molecular Function
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yrk, PDBe:4yrk, PDBj:4yrk
PDBsum4yrk
PubMed26249349
UniProtQ4DA54

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