Structure of PDB 4yr9 Chain A

Receptor sequence
>4yr9A (length=308) Species: 10090 (Mus musculus) [Search protein sequence]
PPRVLITGGLGQLGVGLANLLRKRFGKDNVILSDIRKPPAHVFHSGPFVY
ANILDYKSLREIVVNHRISWLFHYSALLSAVGEANVSLARDVNITGLHNV
LDVAAEYNVRLFVPSTIGAFGPTSPRNPAPDLCIQRPRTIYGVSKVHTEL
MGEYYYYRYGLDFRCLRYPGIISADSPGGGTTDYAVQIFHAAAKNGTFEC
NLEAGTRLPMMYISDCLRATLEVMEAPAERLSMRTYNISAMSFTPEELAQ
ALRKHAPDFQITYCVDPLRQAIAESWPMILDDSNARKDWGWKHDFDLPEL
VATMLNFH
3D structure
PDB4yr9 Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.103: L-threonine 3-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G65 Q66 L67 D88 I89 R90 A105 N106 I107 Y128 S129 A130 L132 P168 T170 Y195 K199 Y222 I225 G11 Q12 L13 D34 I35 R36 A51 N52 I53 Y74 S75 A76 L78 P114 T116 Y141 K145 Y168 I171
BS02 GOL A Y195 T237 W331 Y141 T182 W276
External links
PDB RCSB:4yr9, PDBe:4yr9, PDBj:4yr9
PDBsum4yr9
PubMed26492815
UniProtQ8K3F7|TDH_MOUSE L-threonine 3-dehydrogenase, mitochondrial (Gene Name=Tdh)

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