Structure of PDB 4yr3 Chain A

Receptor sequence

>4yr3A (length=423) Species: 9606 (Homo sapiens)

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTMSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGITEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4yr3 Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 W64 K86 R93 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q41 Y42 W45 W67 K89 R96 P312 K313 T314 G316 C317 S318 K319 N320 P322 R347
BS02	dna	A	S113 E116 S257 G259 G260 K261 L262 R382	S116 E119 S253 G255 G256 K257 L258 R374
BS03	DCP	A	D13 D15 C16 F17 F18 Y52 R55 M61 D115 K231	D16 D18 C19 F20 F21 Y55 R58 M64 D118 K227
BS04	CA	A	D13 M14 D115	D16 M17 D118
BS05	CA	A	D13 D115 E116	D16 D118 E119

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4yr3, PDBe:4yr3, PDBj:4yr3
• PDBsum: 4yr3
• PubMed: 25947374
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)