Structure of PDB 4yq4 Chain A

Receptor sequence
>4yq4A (length=242) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]
GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHK
TVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQG
GVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMT
LIDAVARFIPGVLGDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEI
RKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
3D structure
PDB4yq4 Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
ChainA
Resolution1.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P89 E116 R154 D169
Catalytic site (residue number reindexed from 1) P92 E119 R157 D165
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4G3 A Y86 L87 S88 P89 G117 S132 I133 Y136 L138 G140 P144 Y89 L90 S91 P92 G120 S135 I136 Y139 L141 G143 P147 BindingDB: IC50=1995nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4yq4, PDBe:4yq4, PDBj:4yq4
PDBsum4yq4
PubMed
UniProtP43912|TRMD_HAEIN tRNA (guanine-N(1)-)-methyltransferase (Gene Name=trmD)

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