Structure of PDB 4yq1 Chain A

Receptor sequence
>4yq1A (length=244) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]
GLVPRGSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFT
FDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGR
KLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGE
LPAMTLIDAVARFIPGVLGFADGLLDCPHYTRPEVLEGLTVPPVLMSGHH
EEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHN
3D structure
PDB4yq1 To Be Published
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P89 E116 R154
Catalytic site (residue number reindexed from 1) P97 E124 R162
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4FN A L87 S88 P89 G113 R114 Y115 G117 S132 I133 G134 D135 Y136 V137 L138 G140 P144 L95 S96 P97 G121 R122 Y123 G125 S140 I141 G142 D143 Y144 V145 L146 G148 P152 BindingDB: IC50=5.01nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yq1, PDBe:4yq1, PDBj:4yq1
PDBsum4yq1
PubMed
UniProtP43912|TRMD_HAEIN tRNA (guanine-N(1)-)-methyltransferase (Gene Name=trmD)

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