Structure of PDB 4ymj Chain A

Receptor sequence
>4ymjA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
GIHVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD
PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLN
KFLRAHGPGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN
LLVKIGDFGDVYSTDYYRHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL
WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQRE
PQQRLNIKEIYKILHALGKAT
3D structure
PDB4ymj (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D679 R683 N684 D697 S706
Catalytic site (residue number reindexed from 1) D139 R143 N144 D157 S163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4EJ A G545 V552 A570 K572 F617 Y619 M620 L686 F698 G19 V26 A44 K46 F91 Y93 M94 L146 F158 MOAD: ic50=0.1uM
PDBbind-CN: -logKd/Ki=7.00,IC50=0.1uM
BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ymj, PDBe:4ymj, PDBj:4ymj
PDBsum4ymj
PubMed26005534
UniProtQ16288|NTRK3_HUMAN NT-3 growth factor receptor (Gene Name=NTRK3)

[Back to BioLiP]