Structure of PDB 4yjs Chain A

Receptor sequence
>4yjsA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
YLDRKLLTLEDKELGTVKKGYYQMKKVVKTVAVKILALKDELLAEANVMQ
QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV
HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY
YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG
MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR
LRNYYYD
3D structure
PDB4yjs Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
ChainA
Resolution2.22 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512 K533
Catalytic site (residue number reindexed from 1) D119 A121 R123 N124 D137 K158
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4DN A A400 K402 E420 M448 M450 A451 G454 P455 L501 S511 D512 A32 K34 E45 M73 M75 A76 G79 P80 L126 S136 D137
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yjs, PDBe:4yjs, PDBj:4yjs
PDBsum4yjs
PubMed21903390
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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