Structure of PDB 4yjq Chain A

Receptor sequence
>4yjqA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
YLDRKLLTLEDKELGGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL
LAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK
DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK
ALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS
YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP
GFAAVELRLRNYYYDV
3D structure
PDB4yjq Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
ChainA
Resolution1.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512 K533
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 K166
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4DK A L377 G378 A400 K402 E420 L446 M448 M450 A451 G454 L501 S511 D512 L14 G15 A33 K35 E53 L79 M81 M83 A84 G87 L134 S144 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yjq, PDBe:4yjq, PDBj:4yjq
PDBsum4yjq
PubMed21903390
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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