Structure of PDB 4yhw Chain A

Receptor sequence
>4yhwA (length=133) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TVYHCKVFQFKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVG
NEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMDMHNNSISKTWEGYLQD
CKFKGWFMKVCNDQDSLLRTLGQFDSEHFYSPV
3D structure
PDB4yhw A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A P350 R353 F354 K357 K361 S364 R371 D374 R399 G439 W440 F441 M442 Q457 P16 R19 F20 K23 K27 S30 R37 D40 R65 G105 W106 F107 M108 Q123 PDBbind-CN: Kd=110nM
Gene Ontology
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0046540 U4/U6 x U5 tri-snRNP complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4yhw, PDBe:4yhw, PDBj:4yhw
PDBsum4yhw
PubMed26161500
UniProtQ03338|PRP3_YEAST U4/U6 small nuclear ribonucleoprotein PRP3 (Gene Name=PRP3)

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