Structure of PDB 4yhi Chain A

Receptor sequence

>4yhiA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGE
TNPRNGGTTYNEKFKGKATMTRDTSTSTAYMELSSLRSEDTAVYYCTIGT
SGYDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKD
YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY
ICNVNHKPSNTKVDKKVEPKSC

3D structure

PDB

4yhi Structure-guided residence time optimization of a dabigatran reversal agent.

Chain

Resolution

1.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	4CC	A	D31 Y33 H35 E50 R54 Y103 D104 Y105 F106	D31 Y33 H35 E50 R54 Y103 D104 Y105 F106	MOAD: ic50=4.6nM

External links

PDB	RCSB:4yhi, PDBe:4yhi, PDBj:4yhi
PDBsum	4yhi
PubMed	26047352

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