Structure of PDB 4yhf Chain A

Receptor sequence
>4yhfA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSED
EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR
HRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEI
YSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADE
RPTFKILLSNILDVMDEE
3D structure
PDB4yhf Prolonged and tunable residence time using reversible covalent kinase inhibitors.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 A523 R525 N526 D539 F559
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 F169
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4C9 A V416 A428 K430 M449 V458 I472 T474 Y476 M477 G480 C481 N484 S538 D539 F540 L542 V26 A38 K40 M59 V68 I82 T84 Y86 M87 G90 C91 N94 S148 D149 F150 L152 PDBbind-CN: -logKd/Ki=8.34,IC50=4.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yhf, PDBe:4yhf, PDBj:4yhf
PDBsum4yhf
PubMed26006010
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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