Structure of PDB 4yha Chain A

Receptor sequence
>4yhaA (length=225) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQF
KYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKFKEVA
LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRM
KNSPNQRPVQPDYNTVIIKSSAETR
3D structure
PDB4yha Structural Basis for the Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase by Sulfonamides.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H65 H90 H92 E96 H109 T169
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H110 H112 H129 H90 H92 H109
BS02 MZM A N108 H110 H112 H129 V131 L190 T191 W201 N88 H90 H92 H109 V111 L168 T169 W179 MOAD: Ki=225nM
PDBbind-CN: -logKd/Ki=6.65,Ki=225nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4yha, PDBe:4yha, PDBj:4yha
PDBsum4yha
PubMed26010545
UniProtA0A0M3KL20

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