Structure of PDB 4yh8 Chain A

Receptor sequence
>4yh8A (length=180) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
KVNCSFYYKIGACRHGERCSRKHVKPNFSQTILCPNMYKNPIHEPNGKKF
TQRELAEQFDAFYEDMFCEFSKYGEVEQLVVCDNVGDHLVGNVYVRFKYE
ESAQNAIDDLNSRWYSQRPVYAELSPVTDFREACCRQHETSECQRGGLCN
FMHAKKPSPQLLRDLVLAQRKYLALNAAEE
3D structure
PDB4yh8 A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A C18 C27 C33 H37 C4 C13 C19 H23
BS02 ZN A C149 C157 C163 H167 C135 C143 C149 H153
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030628 pre-mRNA 3'-splice site binding
GO:0046872 metal ion binding
Biological Process
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0071004 U2-type prespliceosome
GO:0089701 U2AF complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4yh8, PDBe:4yh8, PDBj:4yh8
PDBsum4yh8
PubMed26215567
UniProtQ09176|U2AF1_SCHPO Splicing factor U2AF 23 kDa subunit (Gene Name=SPAP8A3.06)

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