Structure of PDB 4yh4 Chain A

Receptor sequence
>4yh4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4yh4 Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
ChainA
Resolution1.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y81 A W81 P82 L92 L94 N140 I146 M149 W40 P41 L51 L53 N99 I105 M108 MOAD: ic50=26uM
PDBbind-CN: -logKd/Ki=4.59,IC50=26uM
BindingDB: IC50=26000nM
External links
PDB RCSB:4yh4, PDBe:4yh4, PDBj:4yh4
PDBsum4yh4
PubMed26022843
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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