Structure of PDB 4ydg Chain A

Receptor sequence
>4ydgA (length=108) Species: 11926 (Human T-cell lymphotrophic virus type 1 (strain ATK)) [Search protein sequence]
PVIPLDPARRPVIKAQVDTQTSHPKTIEALLDTGADMTVIPIALFSSNTP
LKNTTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAIIGRDALQQ
CQGVLYLP
3D structure
PDB4ydg Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G3G A D32 W98 D32 W90 PDBbind-CN: -logKd/Ki=7.82,Ki=0.015uM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ydg, PDBe:4ydg, PDBj:4ydg
PDBsum4ydg
PubMed26000468
UniProtP03362|POL_HTL1A Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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