Structure of PDB 4yc9 Chain A

Receptor sequence
>4yc9A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
SPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRD
LSKPEVEYDCDAPSKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQD
PVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNC
AEFNEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB4yc9 Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
ChainA
Resolution1.82 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C7 C10 H27 C30
BS02 ZN A C841 C844 C867 C870 C19 C22 C45 C48
BS03 4C1 A A923 F924 Q925 D926 V928 V932 F979 N980 A97 F98 Q99 D100 V102 V106 F153 N154 MOAD: Kd=1.3nM
PDBbind-CN: -logKd/Ki=8.89,Kd=1.3nM
BindingDB: Kd=31nM,IC50=7.6nM,EC50=50nM
External links
PDB RCSB:4yc9, PDBe:4yc9, PDBj:4yc9
PDBsum4yc9
PubMed26061247
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

[Back to BioLiP]