Structure of PDB 4ybs Chain A

Receptor sequence
>4ybsA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
PNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDL
SKPEVEYDCDAPKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPV
PLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAE
FNEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB4ybs Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
ChainA
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C6 C9 H26 C29
BS02 ZN A C841 C844 C867 C870 C18 C21 C44 C47
BS03 4BK A A923 F924 V928 F979 N980 E985 V986 A95 F96 V100 F151 N152 E157 V158 MOAD: ic50=0.057uM
PDBbind-CN: -logKd/Ki=7.24,IC50=0.057uM
BindingDB: EC50=1300nM,IC50=<10nM
External links
PDB RCSB:4ybs, PDBe:4ybs, PDBj:4ybs
PDBsum4ybs
PubMed26061247
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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