Structure of PDB 4yat Chain A

Receptor sequence
>4yatA (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
PNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDL
SKPEVEYDKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTV
PDYYKIIKNPMDLSTIKKRLQEDSMYSKPEDFVADFRLIFQNCAEFNEPD
SEVANAGIKLENYFEELLKNLYP
3D structure
PDB4yat Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
ChainA
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C6 C9 H26 C29
BS02 ZN A C841 C844 C867 C870 C18 C21 C44 C47
BS03 4A8 A L922 A923 F924 V928 P929 N980 L90 A91 F92 V96 P97 N147 MOAD: ic50=9.3uM
PDBbind-CN: -logKd/Ki=5.03,IC50=9.3uM
BindingDB: IC50=9300nM
External links
PDB RCSB:4yat, PDBe:4yat, PDBj:4yat
PDBsum4yat
PubMed26061247
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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