Structure of PDB 4yab Chain A

Receptor sequence
>4yabA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
SPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRD
LSKPEVEYDCDAKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPV
PLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAE
FNEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB4yab Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C7 C10 H27 C30
BS02 ZN A C841 C844 C867 C870 C19 C22 C45 C48
BS03 4CN A A923 V928 V932 N980 A95 V100 V104 N152 MOAD: ic50=8.5uM
PDBbind-CN: -logKd/Ki=5.07,IC50=8.5uM
BindingDB: IC50=8500nM
External links
PDB RCSB:4yab, PDBe:4yab, PDBj:4yab
PDBsum4yab
PubMed26061247
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

[Back to BioLiP]