Structure of PDB 4y9l Chain A

Receptor sequence
>4y9lA (length=592) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TITARHTQYSHAKTGGFSQTGPTLHNPYKDDPILDRTLRRLLPESEYMRV
AADLSKFGDRITSEVEHLGRQAELEQPRLEHQDAWGKRVDKLIVCNEWHK
LKQICAEEGVISIGYEDSVDPFVRRIHQVAKLFLFSPSAGLVSCPMAMTD
GAVKTLTSLNLYGKHKLATEAVDRLRSRDPSKAWTSGQWMTEKKGGSDVA
GGCDTYAVQIDKDTYRLHGYKWFSSAVDADVALTLARIVDSDGNALEGSR
GLSLFLLKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGAIAERIGD
QGRGVAGISNMLNITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSK
WPLHTTTLAKMEVDTRGSMLLLFEAARLLGLSEAGKSSDVEAMMLRLITP
VLKLYAGKQAVPMVSEGIECFGGQGYMEDTGLPTLLRDAQVTPIWEGTTN
VLSLDVLRVFSGKENILLAFGKRVEQLLGNTKTEDEKLKKSKEAVESALK
QLQKLLVKASDSAIQGETRIDSVARHIAFTIARIYSGALLIDHASDSSVA
NQSDIEVAYRYCCEQPLIDLRWEWFASERVKADREIVFDNFT
3D structure
PDB4y9l Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
ChainA
Resolution2.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M208 T209 T333 E464 R476
Catalytic site (residue number reindexed from 1) M190 T191 T315 E446 R458
Enzyme Commision number 1.3.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A Q206 M208 T209 G214 S215 F241 S242 S243 W463 T466 L472 Q188 M190 T191 G196 S197 F223 S224 S225 W445 T448 L454
BS02 FAD A R359 V361 F362 Q366 W369 E437 C438 G440 G441 Y444 R341 V343 F344 Q348 W351 E419 C420 G422 G423 Y426
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005504 fatty acid binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006631 fatty acid metabolic process
GO:1990845 adaptive thermogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:4y9l, PDBe:4y9l, PDBj:4y9l
PDBsum4y9l
PubMed25981666
UniProtQ9XWZ2|ACD11_CAEEL Acyl-CoA dehydrogenase family member 11 (Gene Name=acdh-11)

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