Structure of PDB 4y94 Chain A

Receptor sequence
>4y94A (length=158) Species: 9913 (Bos taurus) [Search protein sequence]
ATVILESIFLKRSSPLNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGSID
VEKITCVETVVPEKNPPPERQIPEESSETEQISIIERFPYPFQVVYDEGP
LYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAK
NAMGCQIL
3D structure
PDB4y94 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP A K36 K52 K29 K45 MOAD: Kd=238nM
PDBbind-CN: -logKd/Ki=6.62,Kd=238nM
BS02 IHP A K12 S14 R28 K53 K11 S13 R21 K46 MOAD: Kd=238nM
PDBbind-CN: -logKd/Ki=6.62,Kd=238nM
BS03 ZN A H143 C155 H133 C145
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4y94, PDBe:4y94, PDBj:4y94
PDBsum4y94
PubMed25699547
UniProtQ3ZC95

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