Structure of PDB 4y8d Chain A

Receptor sequence
>4y8dA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
DFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEE
EKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC
KGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKV
ENLLLSNQGTIKLCDFGSATTISHYPYSNFPIGEKQDIWALGCILYLLCF
RQHPFSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARN
VNPKSPITELLE
3D structure
PDB4y8d Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D173 K175 N178 D191
Catalytic site (residue number reindexed from 1) D147 K149 N152 D165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 49J A A67 K69 T123 C126 K127 G128 L180 A41 K43 T97 C100 K101 G102 L154 MOAD: Kd=0.0089uM
PDBbind-CN: -logKd/Ki=8.05,Kd=0.0089uM
BindingDB: Kd=8.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4y8d, PDBe:4y8d, PDBj:4y8d
PDBsum4y8d
PubMed25822739
UniProtO14976|GAK_HUMAN Cyclin-G-associated kinase (Gene Name=GAK)

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