Structure of PDB 4y85 Chain A

Receptor sequence
>4y85A (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSVRYGTVEDLLAFANHISNTPQESGILLNMVITPQNGRYQIDSDVLLI
PWKLTYRNIFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQA
CFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWV
TKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYF
PKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPR
SAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLL
KHEALNP
3D structure
PDB4y85 The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
ChainA
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D253 K255 N258 D270 T290
Catalytic site (residue number reindexed from 1) D170 K172 N175 D187 T207
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 499 A W132 F143 P145 V152 A165 K167 E208 G210 G213 S214 E217 V260 V269 D270 W52 F60 P62 V69 A82 K84 E125 G127 G130 S131 E134 V177 V186 D187 MOAD: ic50=13nM
PDBbind-CN: -logKd/Ki=7.89,IC50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4y85, PDBe:4y85, PDBj:4y85
PDBsum4y85
PubMed25918157
UniProtP41279|M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (Gene Name=MAP3K8)

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