Structure of PDB 4y6u Chain A

Receptor sequence
>4y6uA (length=280) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ALPLDTTWHRPGWTIGELEAAKAGRTISVVLPALNEEATIESVIDSISPL
VDGLVDELIVLDSGSTDDTEIRAIASGARVVSREQALPEVPVRPGKGEAL
WRSLAATSGDIVVFIDSDLINPHPLFVPWLVGPLLTGEGIQLVKSFYRGG
RVTELVARPLLAALRPELGCVLQPLSGEYAASRELLTSLPFAPGYGVEIG
LLIDTFDRLGLDAIAQVNLGVRAHRNRPLDELGAMSRQVIATLLSRCGIP
DSGVGLTQFLYTRHTWPVSLVDRPPMKVMR
3D structure
PDB4y6u A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
ChainA
Resolution2.271 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.266: glucosyl-3-phosphoglycerate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D136 H258 D118 H224
BS02 UPG A P50 A51 L52 E54 S81 G113 K114 D134 S135 D136 L209 Y229 E232 R256 H258 R259 R261 M269 P32 A33 L34 E36 S63 G95 K96 D116 S117 D118 L175 Y195 E198 R222 H224 R225 R227 M235
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006011 UDP-glucose metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4y6u, PDBe:4y6u, PDBj:4y6u
PDBsum4y6u
PubMed26136334
UniProtP9WMW9|GPGS_MYCTU Glucosyl-3-phosphoglycerate synthase (Gene Name=gpgS)

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