Structure of PDB 4y6d Chain A

Receptor sequence
>4y6dA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNV
APACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRN
SCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVS
WGEGCARKGKYGIYTKVTAFLKWIDRSMKT
3D structure
PDB4y6d TBA
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D84 Q178 G179 D180 S181 G182
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 48U A T98 Y99 F174 D189 A190 Q192 V213 W215 G216 G226 I227 Y228 T80 Y81 F158 D175 A176 Q178 V199 W201 G202 G212 I213 Y214 BindingDB: IC50=4.83nM,Ki=1.5nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4y6d, PDBe:4y6d, PDBj:4y6d
PDBsum4y6d
PubMed
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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