Structure of PDB 4y62 Chain A

Receptor sequence
>4y62A (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
SLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNT
TIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTL
GTGRQLSVLEVRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRD
HVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYGGA
FFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKV
LSPEYLWDQQLLGWPAVLRKLRFTAVP
3D structure
PDB4y62 Design of Glycosyltransferase Inhibitors: Serine Analogues as Pyrophosphate Surrogates?
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H233 G266 W300 E303 A343
Catalytic site (residue number reindexed from 1) H165 G198 W232 E235 A275
Enzyme Commision number 2.4.1.37: fucosylgalactoside 3-alpha-galactosyltransferase.
2.4.1.40: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BHE A H233 G235 F236 T245 W300 E303 D326 H165 G167 F168 T177 W232 E235 D258
BS02 48E A F121 I123 Y126 W181 S185 D211 V212 D213 H301 F57 I59 Y62 W113 S117 D143 V144 D145 H233 PDBbind-CN: -logKd/Ki=2.95,IC50=1133uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003823 antigen binding
GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
GO:0004381 fucosylgalactoside 3-alpha-galactosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0030259 lipid glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031982 vesicle
GO:0032580 Golgi cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4y62, PDBe:4y62, PDBj:4y62
PDBsum4y62
PubMed
UniProtP16442|BGAT_HUMAN Histo-blood group ABO system transferase (Gene Name=ABO)

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