Structure of PDB 4y4l Chain A

Receptor sequence
>4y4lA (length=303) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
VTHCLSDIVKKEDWSDFKFAPIRESTVSRAMTSRYFKDLDKFAVSDVIIV
GAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGGGSWLGGQLFSAMVMRKP
AHLFLQELEIPYEDEGDYVVVKHAALFISTVLSKVLQLPNVKLFNATCVE
DLVTRPPTEKGEVTVAGVVTNWTLVTQAHGTCSMDPNVIELAGYKNDGTR
DLSQKHGVILSTTGHDGPFGAFCAKRIVDIDQNQKLGGMKGLDMNHAEHD
VVIHSGAYAGVDNMYFAGMEVAELDGLNRMGPTFGAMALSGVHAAEQILK
HFA
3D structure
PDB4y4l Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.60: cysteine-dependent adenosine diphosphate thiazole synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 48N A G72 S75 S76 E97 S98 G104 G105 C169 V170 T235 G236 F241 G290 M291 R301 M302 G303 M309 G51 S54 S55 E76 S77 G83 G84 C148 V149 T213 G214 F219 G268 M269 R279 M280 G281 M287
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0016740 transferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0009228 thiamine biosynthetic process
GO:0052837 thiazole biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4y4l, PDBe:4y4l, PDBj:4y4l
PDBsum4y4l
PubMed26919468
UniProtP32318|THI4_YEAST Thiamine thiazole synthase (Gene Name=THI4)

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