Structure of PDB 4y0a Chain A

Receptor sequence
>4y0aA (length=179) Species: 557600 (Acinetobacter baumannii AB307-0294) [Search protein sequence]
PSKAFETLPNIYLVGPMGAGKTTVGRHLAELLGREFLDSDHEIERKTGAT
IPWIFEKEGEVGFRTRETVVLNELTSRKALVLATGGGAITQAPNREFLKQ
RGIVVYLYTPVELQLQRTYRDKNRPLLQVENPEQKLRDLLKIRDPLYREV
AHYTIETNQGAARDLAQKILQLILSNKLK
3D structure
PDB4y0a Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate.
ChainA
Resolution1.911 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.71: shikimate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SKM A M27 D50 F73 R74 G96 G97 L136 R153 M17 D40 F63 R64 G86 G87 L126 R143 PDBbind-CN: -logKd/Ki=2.31,Ki=4950uM
BS02 SO4 A E122 R147 E112 R137
BS03 SO4 A G28 A29 G30 K31 T32 R134 G18 A19 G20 K21 T22 R124
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0016310 phosphorylation
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4y0a, PDBe:4y0a, PDBj:4y0a
PDBsum4y0a
PubMed26249354
UniProtA0A0M3KL09

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