Structure of PDB 4xz3 Chain A

Receptor sequence
>4xz3A (length=463) Species: 374847 (Candidatus Korarchaeum cryptofilum OPF8) [Search protein sequence]
NDLERLFNPSAIAVVGASKDPSKIGSQILRNLLSYGFKGKVYPINPTADE
LMGLKCYPKVSDVPDKVDVAVISVPSDKVLGVIDDCGKAGVKFAVVITSG
FKEVGNEELEEELVRRAHSYGMRVLGPNIFGYLYAPARLNATFGPKDVLS
GNVAFISQSGALGIALMGYTVVENIGISSIVSVGNKADLDDVDLLDFFDK
DPNTGVIMIYLEGIAPGRGRMFIDVASRVSLRKPIIVIKAGRTEVGARAA
ASHTGSIAGSVAIYESAFKQSGILMAKSVEDAFDWTKALSWNPIPEGERL
IVLTNGGGAGVQSTDTFADNGIYLSKPPESLIQEIKKFVPPFASFANPID
ITGMAPDDWYYMGTLAALKNPDVDALTVLYCQTAVTTPIGVAKGIVDAIK
EAGNSKPVTVGMVGGPEVAEAVSFLNKQRIAAYPTPERASSAMSALYAYA
RARSYVMKSLAVR
3D structure
PDB4xz3 Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer.
ChainA
Resolution2.398 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I215 H254
Catalytic site (residue number reindexed from 1) I214 H253
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A G17 S19 K24 I25 N46 P47 S74 V75 P76 K79 V83 I98 T99 S100 N129 I130 G16 S18 K23 I24 N45 P46 S73 V74 P75 K78 V82 I97 T98 S99 N128 I129
BS02 ACP A G308 G309 F343 A344 S345 G307 G308 F342 A343 S344
BS03 ACP A S160 G161 A162 S159 G160 A161
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0043758 acetate-CoA ligase (ADP-forming) activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4xz3, PDBe:4xz3, PDBj:4xz3
PDBsum4xz3
PubMed26787904
UniProtB1L3C9

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