Structure of PDB 4xz2 Chain A

Receptor sequence
>4xz2A (length=708) Species: 9606 (Homo sapiens) [Search protein sequence]
SAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNI
AEADWESVQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKE
WSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIMTIGTDSALHRIIEVV
DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGW
EEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGY
DTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLN
GNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLA
IKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYD
GFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTH
SINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDF
SIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAA
GADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTD
FIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWIT
AKLKEAFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKL
RPLMKILA
3D structure
PDB4xz2 Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation.
ChainA
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G34 D128 G172 S173 R219
Catalytic site (residue number reindexed from 1) G10 D88 G132 S133 R171
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A G233 K264 R430 R434 G467 G468 G185 K216 R382 R386 G419 G420
BS02 FBP A A420 R481 V539 S540 M583 E639 H671 Q674 A372 R433 V491 S492 M535 E591 H623 Q626
BS03 F6P A R210 R301 R162 R253
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
GO:0070095 fructose-6-phosphate binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0061621 canonical glycolysis
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xz2, PDBe:4xz2, PDBj:4xz2
PDBsum4xz2
PubMed26205495
UniProtQ01813|PFKAP_HUMAN ATP-dependent 6-phosphofructokinase, platelet type (Gene Name=PFKP)

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