Structure of PDB 4xz1 Chain A

Receptor sequence
>4xz1A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVH
DVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC
NRPSGLEPQPGVFDSLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKL
IATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSL
IYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKE
ACPN
3D structure
PDB4xz1 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R17 R37 R41 H57 H58 F59 P60 R170 R190 R192 Y209 H210 Y211 I223 G226 Y238 D244 G245 R15 R35 R39 H55 H56 F57 P58 R168 R188 R190 Y207 H208 Y209 I221 G224 Y236 D242 G243
BS02 4N6 A N66 G67 T68 C78 N64 G65 T66 C76
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:4xz1, PDBe:4xz1, PDBj:4xz1
PDBsum4xz1
PubMed25287889
UniProtP43403|ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (Gene Name=ZAP70)

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