Structure of PDB 4xx5 Chain A

Receptor sequence

>4xx5A (length=843) Species: 9606 (Homo sapiens)

SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDP
KLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGA
ILQSFFTKMAKQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVV
LDTPPDPALDEVRKEEWCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQH
GQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCRLLY
YVNLLLIDHRFLLRRGEYVLHMWQISGFNADKLTSATNPDKENSMSISIL
LDNHPIARAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHP
KAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFS
DENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGL
RNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQV
QVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVP
YDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGD
DLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDAT
TIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYC
VATFVLGIGDRHNDNIMITETGNLFHIDFGHERVPFVLTPDFLFVMGTSG
KKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIE
YIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL

3D structure

• PDB: 4xx5 Structure of PI3K gamma in complex with an inhibitor
• Chain: A
• Resolution: 2.76 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.1.137: phosphatidylinositol 3-kinase.
  2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
  2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	43R	A	W812 I831 Y867 I879 I881 V882 A885 M953 I963 D964	W576 I595 Y631 I643 I645 V646 A649 M717 I727 D728	BindingDB: Ki=0.048000nM

Gene Ontology

Molecular Function

• GO:0016301 kinase activity

Biological Process

• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:4xx5, PDBe:4xx5, PDBj:4xx5
• PDBsum: 4xx5
• UniProt: P48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)