Structure of PDB 4xvy Chain A

Receptor sequence
>4xvyA (length=248) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
STGVELYLDLLKRTVSNFIYQDATHVAGLIAFVEEARESGEDYPTVAHTM
IGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAYDVRD
RTVWVADSFQGFPKITDDDHPMDAEMNLHQYNEAVDLPTSLATVQRNFSR
YGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTHAYPR
LSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRRSA
3D structure
PDB4xvy Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.237: mycinamicin III 3''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D189 D191 D216 D217 D183 D185 D210 D211
BS02 SAH A T55 M56 I57 E83 G85 V86 W87 D113 S114 G117 F118 L143 W170 F171 D189 T49 M50 I51 E77 G79 V80 W81 D107 S108 G111 F112 L137 W164 F165 D183
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xvy, PDBe:4xvy, PDBj:4xvy
PDBsum4xvy
PubMed25692963
UniProtQ49492|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

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