Structure of PDB 4xvr Chain A

Receptor sequence
>4xvrA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKD
SDDVPMVLVGNKCDLAARTVESRQAQDLARSFGIPYIETSAKTRQGVEDA
FYTLVREIRQH
3D structure
PDB4xvr Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
ChainA
Resolution2.031 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S17 T35
BS02 GNP A G13 G15 K16 S17 A18 F28 D30 T35 G60 N116 K117 D119 L120 S145 A146 K147 G13 G15 K16 S17 A18 F28 D30 T35 G60 N111 K112 D114 L115 S140 A141 K142
BS03 CA A R102 D105 R97 D100
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4xvr, PDBe:4xvr, PDBj:4xvr
PDBsum4xvr
PubMed25999467
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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