Structure of PDB 4xvm Chain A

Receptor sequence

>4xvmA (length=627) Species: 9606 (Homo sapiens)

KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARN
VLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAW
LIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTL
YRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLKYPSTSEA
VLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKKILTISPRAMFVSSKGHTFLAADF
SQIELRILTHLSGDPELLKLDDVFSTLTSQWKDVPVEQVTHADREQTKKV
VYAVVYGAGKERLAACVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQT
GCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIH
VFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQ
ALELQLQVPLKVSLSAGRSWGHLVPLQ

3D structure

• PDB: 4xvm How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
• Chain: A
• Resolution: 3.2 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	H539 S543 T544 T567 V568 A574 H576 N578 A683 Y686 A688 G689 R692 R743 R761 Q762 N765 Q769	H322 S326 T327 T350 V351 A357 H359 N361 A453 Y456 A458 G459 R462 R511 R529 Q530 N533 Q537
BS02	dna	A	R571 Q580 G581 S583 K584 R608 E628 K679 Y682 Y686 I801 H802 D803	R354 Q363 G364 S366 K367 R384 E404 K449 Y452 Y456 I569 H570 D571

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication

External links

• PDB: RCSB:4xvm, PDBe:4xvm, PDBj:4xvm
• PDBsum: 4xvm
• PubMed: 25775266
• UniProt: Q7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)