Structure of PDB 4xvi Chain A

Receptor sequence
>4xviA (length=647) Species: 9606 (Homo sapiens) [Search protein sequence]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQAEGCGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFA
RNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIA
AWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLK
TLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEK
TSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNS
LPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLAC
MKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKKILTISPRA
MFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQRDDVFSTLTSQWK
DVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFL
QKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQ
AVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDP
QIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQ
3D structure
PDB4xvi How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
ChainA
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T514 E516 R536 K540 R571 Q580 S583 Y686 D803 T312 E314 R334 K338 R369 Q378 S381 Y474 D591
BS02 dna A T479 S480 S543 T544 T567 V568 A574 K575 H576 N578 Y686 R743 Q762 T277 S278 S341 T342 T365 V366 A372 K373 H374 N376 Y474 R531 Q550
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xvi, PDBe:4xvi, PDBj:4xvi
PDBsum4xvi
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

[Back to BioLiP]