Structure of PDB 4xum Chain A

Receptor sequence
>4xumA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
3D structure
PDB4xum Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMN A F282 C285 S289 H323 F360 F363 H449 Y473 F65 C68 S72 H106 F143 F146 H232 Y256 MOAD: ic50=21.3uM
PDBbind-CN: -logKd/Ki=4.67,IC50=21.3uM
BindingDB: EC50=50000nM
BS02 IMN A E259 R280 I281 C285 I341 S342 M348 E53 R63 I64 C68 I124 S125 M131 MOAD: ic50=21.3uM
PDBbind-CN: -logKd/Ki=4.67,IC50=21.3uM
BindingDB: EC50=50000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xum, PDBe:4xum, PDBj:4xum
PDBsum4xum
PubMed26445566
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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