Structure of PDB 4xua Chain A

Receptor sequence
>4xuaA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVI
KKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
NMRKYFEKKWTDTFKV
3D structure
PDB4xua Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 43C A W1887 P1888 L1890 L1891 V1893 N1894 V1898 I1950 W32 P33 L35 L36 V38 N39 V43 I95 MOAD: ic50=26uM
PDBbind-CN: -logKd/Ki=4.59,IC50=26uM
External links
PDB RCSB:4xua, PDBe:4xua, PDBj:4xua
PDBsum4xua
PubMed25719566
UniProtQ9UIF8|BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (Gene Name=BAZ2B)

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