Structure of PDB 4xu1 Chain A

Receptor sequence
>4xu1A (length=263) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGAD
IDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLS
LAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVV
LGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWR
NANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGG
RTVVVSAGDVVHL
3D structure
PDB4xu1 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
ChainA
Resolution1.70001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R69 K138
Catalytic site (residue number reindexed from 1) R67 K136
Enzyme Commision number 6.3.4.15: biotin--[biotin carboxyl-carrier protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 44O A S38 T39 N40 Q63 G66 R67 G68 R69 R72 W74 A75 I83 K138 G141 I142 V155 G156 N158 V166 D167 A170 S36 T37 N38 Q61 G64 R65 G66 R67 R70 W72 A73 I81 K136 G139 I140 V153 G154 N156 V164 D165 A168 MOAD: Kd=0.324nM
PDBbind-CN: -logKd/Ki=9.49,Kd=0.324nM
Gene Ontology
Molecular Function
GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008284 positive regulation of cell population proliferation
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xu1, PDBe:4xu1, PDBj:4xu1
PDBsum4xu1
PubMed26299766
UniProtI6YFP0|BIRA_MYCTU Biotin--[acetyl-CoA-carboxylase] ligase (Gene Name=birA)

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