Structure of PDB 4xt9 Chain A

Receptor sequence
>4xt9A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB4xt9 Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 I350 E504 K72 I86 E240
BS02 43V A Q286 L287 C320 L324 R364 M365 R367 A368 V376 F377 F388 I400 F401 Q22 L23 C56 L60 R100 M101 R103 A104 V112 F113 F124 I136 F137 PDBbind-CN: -logKd/Ki=6.80,IC50=0.16uM
BindingDB: IC50=158nM,EC50=3162nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xt9, PDBe:4xt9, PDBj:4xt9
PDBsum4xt9
PubMed26277758
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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