Structure of PDB 4xt7 Chain A

Receptor sequence

>4xt7A (length=246) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]

PLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAM
AGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQS
EVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEV
IACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELC
LTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT

3D structure

PDB

4xt7 Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	F45 I46 A53 T54 G57 S59 G84 V85 G86 T87 I90 E91 V120 T121 R122 S123 V173 E175 E193 G195 P196 T197 L198 T201	F33 I34 A41 T42 G45 S47 G72 V73 G74 T75 I78 E79 V108 T109 R110 S111 V161 E163 E181 G183 P184 T185 L186 T189
BS02	TOP	A	N44 F45 I46 S59 G60 D67 R68 F71 E91 T214	N32 F33 I34 S47 G48 D55 R56 F59 E79 T202	MOAD: ic50=93.5uM

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0008703	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
GO:0016491	oxidoreductase activity

	Biological Process
GO:0009231	riboflavin biosynthetic process

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4xt7, PDBe:4xt7, PDBj:4xt7
PDBsum	4xt7
PubMed	26848874
UniProt	P71968

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