Structure of PDB 4xt6 Chain A

Receptor sequence
>4xt6A (length=237) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PLRLLSSVHYLTGELPQLYDYPDDGTWLRANFISSLDGGATVTSGAMAGP
GDRFVFNLLRELADVIVVGVGTVRVRMGVVQRQHRQARGQSEVPQLAIVT
RSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPG
TVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVG
GLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT
3D structure
PDB4xt6 Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G84 V85 G86 T87 V120 T121 R122 S123 V173 G195 P196 T197 L198 T201 G69 V70 G71 T72 V99 T100 R101 S102 V152 G174 P175 T176 L177 T180
BS02 44V A N44 F45 I46 S59 D67 F71 E193 N31 F32 I33 S44 D52 F56 E172
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0009231 riboflavin biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4xt6, PDBe:4xt6, PDBj:4xt6
PDBsum4xt6
PubMed26848874
UniProtP71968

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