Structure of PDB 4xt5 Chain A

Receptor sequence
>4xt5A (length=246) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAM
AGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQS
EVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEV
IACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELC
LTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT
3D structure
PDB4xt5 Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
ChainA
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A F45 I46 A53 T54 G57 S59 G84 V85 G86 T87 I90 E91 V120 T121 R122 S123 V173 E175 E193 G194 G195 P196 T197 L198 T201 F33 I34 A41 T42 G45 S47 G72 V73 G74 T75 I78 E79 V108 T109 R110 S111 V161 E163 E181 G182 G183 P184 T185 L186 T189
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0009231 riboflavin biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4xt5, PDBe:4xt5, PDBj:4xt5
PDBsum4xt5
PubMed26848874
UniProtP71968

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