Structure of PDB 4xt4 Chain A

Receptor sequence
>4xt4A (length=246) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAM
AGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQS
EVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEV
IACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELC
LTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT
3D structure
PDB4xt4 Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
ChainA
Resolution1.891 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G84 V85 G86 T87 V120 T121 R122 S123 V173 E175 G195 P196 T197 L198 T201 G72 V73 G74 T75 V108 T109 R110 S111 V161 E163 G183 P184 T185 L186 T189
BS02 44W A N44 F45 I46 D67 F71 E91 N32 F33 I34 D55 F59 E79
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0009231 riboflavin biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4xt4, PDBe:4xt4, PDBj:4xt4
PDBsum4xt4
PubMed26848874
UniProtP71968

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