Structure of PDB 4xt2 Chain A

Receptor sequence
>4xt2A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
GEFKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHA
LDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQ
PQCIMCVNYVLSEIEK
3D structure
PDB4xt2 Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
ChainA
Resolution1.698 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 43L A H248 M252 Y281 M289 S292 H293 L296 V302 S304 Y307 M309 G323 H15 M19 Y48 M56 S59 H60 L63 V69 S71 Y74 M76 G90 MOAD: Kd=63nM
PDBbind-CN: -logKd/Ki=7.15,Kd=70nM
BindingDB: Kd=63nM,IC50=112nM
External links
PDB RCSB:4xt2, PDBe:4xt2, PDBj:4xt2
PDBsum4xt2
PubMed26226049
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

[Back to BioLiP]