Structure of PDB 4xt1 Chain A

Receptor sequence
>4xt1A (length=291) Species: 10358 (Cytomegalovirus) [Search protein sequence]
DYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRI
QCSGDVYFINLAAADLLFVCTLPLWMQYLLDSVPCTLLTACFYVAMFASL
CFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKK
DNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQ
SRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSL
KRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFR
3D structure
PDB4xt1 Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
ChainA
Resolution2.886 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A A272 L279 A253 L260
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0019957 C-C chemokine binding
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0019049 virus-mediated perturbation of host defense response
GO:0019722 calcium-mediated signaling
GO:0044864 positive regulation by virus of host cell division
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0020002 host cell plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xt1, PDBe:4xt1, PDBj:4xt1
PDBsum4xt1
PubMed25745166
UniProtP69332|US28_HCMVA G-protein coupled receptor homolog US28 (Gene Name=US28)

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